COcoa Supplement and

Multivitamin Outcomes Study

Who is eligible?


Women aged 65 years and older

 


    • Have not had a heart attack or stroke

    • Have not had cancer in the past 2 years (excluding skin cancer)


Men aged 60 years and older

 


    • Have not had a heart attack or stroke

    • Have not had cancer in the past 2 years (excluding skin cancer)



Participants are asked to:


1) Take 3 study pills every day for 4 years:

 


    • 2 cocoa extract or placebo capsules and 1 multivitamin or placebo tablet

    • The placebos look exactly like the cocoa extract or multivitamin, but contain none of the active ingredients



2) Avoid outside use of:

 


    • Cocoa extract supplements (Eating chocolate is allowed!)

    • Multivitamins, including eye vitamins like PreserVision, Ocuvite and AREDS



3) Limit daily supplement intake:

 


    • Vitamin D: 1000 IU/day maximum

    • Calcium: 1200 mg/day maximum



4) Complete health and diet questionnaires



5) Provide consent to obtain medical records related to new cases of heart disease, cancer, or other health outcomes



6) Join sub-studies that include possible compensation (optional)

 



All information provided will be held strictly confidential and used only for medical research purposes.

 

 


























COSMOS Trial

Brigham and Women’s Hospital  | Division of Preventive Medicine | 900 Commonwealth Avenue  |  Boston, MA  02215  |  800-633-6913

COSMOStrial@partners.org