COSMOS-Related Publications

Sachs BC, Williams BJ, Gaussoin SA, Baker LD, Manson JE, Espeland MA, Sesso HD, Shumaker SA, Rapp SR; COSMOS-Mind Research Group. Impact of multivitamin-mineral and cocoa extract on incidence of mild cognitive impairment and dementia: Results from the COcoa Supplement and Multivitamin Outcomes Study for the Mind (COSMOS-Mind). Alzheimers Dement. 2023 Apr 10. doi: 10.1002/alz.13078. Epub ahead of print. PMID: 37035889.

Baker LD, Manson JE, Rapp SR, Sesso HD, Gaussoin SA, Shumaker SA, Espeland MA. Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial. Alzheimers Dement. 2023 Apr;19(4):1308-1319. doi: 10.1002/alz.12767. Epub 2022 Sep 14. PMID: 36102337; PMCID: PMC10011015.

Bailey RL, Dog TL, Smith-Ryan AE, Das SK, Baker FC, Madak-Erdogan Z, Hammond BR, Sesso HD, Eapen A, Mitmesser SH, Wong A, Nguyen H. Sex Differences Across the Life Course: A Focus On Unique Nutritional and Health Considerations among Women. J Nutr. 2022 Jul 6;152(7):1597-1610. doi: 10.1093/jn/nxac059. PMID: 35294009; PMCID: PMC9258555.

Sesso HD, Manson JE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, Copeland T, Clar A, Mora S, Moorthy MV, Sarkissian A, Carrick WR, Anderson GL; COSMOS Research Group. Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial. Am J Clin Nutr. 2022 Jun 7;115(6):1490-1500. doi: 10.1093/ajcn/nqac055. PMID: 35294962; PMCID: PMC9170467.

Sesso HD, Rist PM, Aragaki AK, Rautiainen S, Johnson LG, Friedenberg G, Copeland T, Clar A, Mora S, Moorthy MV, Sarkissian A, Wactawski-Wende J, Tinker LF, Carrick WR, Anderson GL, Manson JE; COSMOS Research Group. Multivitamins in the prevention of cancer and cardiovascular disease: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial. Am J Clin Nutr. 2022 Jun 7;115(6):1501-1510. doi: 10.1093/ajcn/nqac056. PMID: 35294969; PMCID: PMC9170475.

Rist PM, Sesso HD, Johnson LG, Aragaki AK, Wang L, Rautiainen S, Hazra A, Tobias DK, LeBoff MS, Schroeter H, Friedenberg G, Copeland T, Clar A, Tinker LF, Hunt RP, Bassuk SS, Sarkissian A, Smith DC, Pereira E, Carrick WR, Wion ES, Schoenberg J, Anderson GL, Manson JE; COSMOS Research Group. Design and baseline characteristics of participants in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS). Contemp Clin Trials. 2022 May;116:106728. doi: 10.1016/j.cct.2022.106728. Epub 2022 Mar 12. PMID: 35288332; PMCID: PMC9133193.

Prentice RL, Howard BV, Van Horn L, Neuhouser ML, Anderson GL, Tinker LF, Lampe JW, Raftery D, Pettinger M, Aragaki AK, Thomson CA, Mossavar-Rahmani Y, Stefanick ML, Cauley JA, Rossouw JE, Manson JE, Chlebowski RT. Nutritional epidemiology and the Women’s Health Initiative: a review. Am J Clin Nutr. 2021 May 8;113(5):1083-1092. doi: 10.1093/ajcn/nqab091. PMID: 33876183; PMCID: PMC8120331.

Greenberg JA, Neuhouser ML, Tinker LF, Lane DS, Paskett ED, Van Horn LV, Wassertheil-Smoller S, Shikany JM, Qi L, Sealy-Jefferson S, Manson JE. Chocolate Candy and Incident Invasive Cancer Risk in the Women’s Health Initiative: An Observational Prospective Analysis. J Acad Nutr Diet. 2021 Feb;121(2):314-326.e4. doi: 10.1016/j.jand.2020.06.014. Epub 2020 Aug 4. PMID: 32763064.

Limonte CP, Zelnick LR, Ruzinski J, Hoofnagle AN, Thadhani R, Melamed ML, Lee IM, Buring JE, Sesso HD, Manson JE, de Boer IH. Effects of long-term vitamin D and n-3 fatty acid supplementation on inflammatory and cardiac biomarkers in patients with type 2 diabetes: secondary analyses from a randomised controlled trial. Diabetologia. 2021 Feb;64(2):437-447. doi: 10.1007/s00125-020-05300-7. Epub 2020 Oct 24. Erratum in: Diabetologia. 2020 Dec 10;: PMID: 33098434; PMCID: PMC7855668.

Rist PM, Sesso HD, Manson JE. Innovation in the design of large-scale hybrid randomized clinical trials. Contemp Clin Trials. 2020 Dec;99:106178. doi: 10.1016/j.cct.2020.106178. Epub 2020 Oct 18. PMID: 33086158; PMCID: PMC7568770.

Prentice RL, Pettinger M, Neuhouser ML, Tinker LF, Huang Y, Zheng C, Manson JE, Mossavar-Rahmani Y, Anderson GL, Lampe JW. Can dietary self-reports usefully complement blood concentrations for estimation of micronutrient intake and chronic disease associations? Am J Clin Nutr. 2020 Jul 1;112(1):168-179. doi: 10.1093/ajcn/nqaa034. PMID: 32133498; PMCID: PMC7326592.

Chen L, Zhu H, Gutin B, Sesso HD, Dong Y. Higher chocolate intake is associated with longer telomere length among adolescents. Pediatr Res 2020; 87(3):602-607. doi: 10.1038/s41390-019-0590-6. Epub 2019 Oct 1. PMID: 31574531

Baker LD, Rapp SR, Shumaker SA, Manson JE, Sesso HD, Gaussoin SA, Harris D, Caudle B, Pleasants D, Espeland MA. Design and baseline characteristics of the cocoa supplement and multivitamin outcomes study for the Mind: COSMOS-Mind. Contemp Clin Trials 2019;83:57-63. doi:10.1016/j.cct.2019.06.019. Epub 2019 Jul 5. PMCID: PMC6642834

Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D’Agostino D, Friedenberg G, Ridge C, Bubes V, Giovannucci EL, Willett WC, Buring JE; for the VITAL Research Group. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 2019 Jan 3;380:33-44. doi: 10.1056/NEJMoa1809944. Epub 2018 Nov 10.

Greenberg JA, Manson JE, Neuhouser ML, et al. Chocolate intake and heart disease and stroke in the Women’s Health Initiative: a prospective analysis. Am J Clin Nutr 2018,108:41-48.

Prentice RL, Pettinger M, Neuhouser ML, Tinker LF, Huang Y, Zheng C, Manson JE, Mossavar-Rahmani Y, Anderson GL, Lampe JW. Application of blood concentration biomarkers in nutritional epidemiology: example of carotenoid and tocopherol intake in relation to chronic disease risk. Am J Clin Nutr 2019 Apr 1;109:1189-1196. doi: 10.1093/ajcn/nqy360.

Blumberg JB, Bailey RL, Sesso HD, Ulrich CM. The evolving role of multivitamin/multimineral supplement use among adults in the age of personalized nutrition. Nutrients. 2018 Feb 22;10(2). pii: E248. doi: 10.3390/nu10020248. PMID: 29470410

Manson JE, Bassuk SS. Vitamin and mineral supplements: what clinicians need to know. JAMA 2018;319:859-860. (Viewpoint)

Bischoff-Ferrari HA, Bhasin S, Manson JE. Preventing fractures and falls: a limited role for calcium and vitamin D supplements. JAMA 2018;319:1552-1553. (Editorial)

Greenberg JA, Manson JE, Tinker L, Neuhouser ML, Garcia L, Vitolins MZ, Phillips LS. Chocolate intake and diabetes risk in postmenopausal American women. Eur J Clin Nutr 2017;71(9):1088–1093. doi: 10.1038/ejcn.2017.36. Epub 2017 Apr 12.

Rautiainen S, Sesso HD, Manson JE. Large-scale randomized clinical trials of bioactives and nutrients in relation to human health and disease prevention – Lessons from the VITAL and COSMOS trials. Mol Aspects Med 2017 Dec 29. pii: S0098-2997(17)30090-0. doi: 10.1016/j.mam.2017.12.001. Epub 2017 Dec 29. PMCID: PMC6004238

Rautiainen S, Gaziano JM, Christen WG, Bubes V, Kotler G, Glynn RJ, Manson JE, Buring JE, Sesso HD. Effect of baseline nutritional status on long-term multivitamin use and cardiovascular disease risk: a secondary analysis of the Physicians’ Health Study II randomized clinical trial. JAMA Cardiol 2017. Epub 2017 Apr 5. doi:10.1001/jamacardio.2017.0176

Rautiainen S, Wang L, Lee IM, Manson JE, Gaziano JM, Buring JE, Sesso HD. Multivitamin use and the risk of hypertension in a prospective cohort study of women. J Hypertens 2016;34:1513-1519. PMCID: PMC4927371

Lin X, Zhang I, Li A, Manson JE, Sesso HD, Wang L, Liu S. Cocoa flavanol intake and biomarkers for cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials. J Nutr 2016;146:2325-2333. Epub 2016 Sep 28. PMCID: PMC5086796

Rautiainen S, Manson JE, Lichtenstein AH, Sesso HD. Dietary supplements and disease prevention – a global overview. Nat Rev Endocrinol 2016;12:407-420. PMID: 27150288

Rautiainen S, Rist PM, Glynn RJ, Buring JE, Gaziano JM, Sesso HD. Multivitamin use and the risk of cardiovascular disease in men. J Nutr 2016;146:1235-1240. Epub 2016 Apr 27. PMCID: PMC4877630

Greenberg JA, Manson JE, Buijsse B, Wang L, Allison MA, Neuhouser ML, Tinker L, Waring ME, Isasi CR, Martin LW, Thomson CA. Chocolate-candy consumption and 3-year weight gain among postmenopausal U.S. women. Obesity 2015; 23(3):677-683. PMCID4351742

Rautiainen S, Lee IM, Rist PM, Gaziano JM, Manson JE, Buring JE, Sesso HD. Multivitamin use and cardiovascular disease in a prospective study of women. Am J Clin Nutr 2015; 101(1):144-152. PMCID4266884

Schroeter H, Keen CL, Sesso HD, Manson JE, Lupton JR. Is this the end of (-)-epicatechin, or not? New study highlights the complex challenges associated with research into the cardiovascular health benefits of bioactive food constituents. Am J Clin Nutr 2015; 102(4):975-976. (Letter)

Matsumoto C, Petrone AB, Sesso HD, Gaziano JM, Djoussé L. Chocolate consumption and risk of diabetes mellitus in the Physicians’ Health Study. Am J Clin Nutr 2015;101:362-367. Epub 2014 Nov 26. PMCID: PMC4307206